JAMA Associate Editor Preeti Malani, MD, MSJ, discusses the transmission, diagnosis, and treatment of monkeypox and the 2022 outbreak with Jeannette Guarner, MD, and Carlos del Rio, MD, both of the Division of Infectious Diseases at Emory University’s School of Medicine. Recorded July 11, 2022.
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Barrett esophagus affects approximately 5% of people in the US and approximately 1% worldwide; it's associated with an increased risk of esophageal adenocarcinoma. JAMA Deputy Editor Mary M. McDermott, MD, interviews Prateek Sharma, MD, a gastroenterologist and professor of medicine at University of Kansas School of Medicine, about the diagnosis, surveillance, and available therapy for patients affected by Barrett esophagus.
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Malaria is diagnosed in approximately 2000 people in the US each year. Delay in diagnosis or inappropriate treatment of malaria is associated with increased mortality. In this podcast, JAMA Deputy Editor Mary M. McDermott, MD, interviews Johanna P. Daily, MD, MS, Albert Einstein College of Medicine, an infectious disease expert and scientist studying malaria, on the diagnosis, treatment, and prevention of malaria in the US.
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Pregnancy inherently increases the risk of death, but certain conditions during pregnancy are considered life-threatening. In this podcast, JAMA Associate Editor Linda Brubaker, MD, discusses with maternal-fetal medicine specialists William A. Grobman, MD, The Ohio State University, and Cynthia Gyamfi-Bannerman, MD, MS, University of California, San Diego, the categories of life-threatening conditions, as well as the racial and ethnic disparities associated with pregnancy-associated mortality.
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In the US, approximately 100 000 people have sickle cell disease, a chronic condition characterized by hemolytic anemia, acute and chronic pain, increased rates of stroke and nephropathy, and an average lifespan that is 20 years less than that of the general population. In this podcast, JAMA Deputy Editor Mary McDermott, MD, interviews review article author Patricia Kavanaugh, MD, on the diagnosis and management of sickle cell disease. Discussion includes a summary of 3 new therapies for sickle cell disease and some of the social, structural, and cultural challenges encountered by patients with sickle cell disease.
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In July 2022, Kirsten Bibbins-Domingo, PhD, MD, MAS, took on a new role as the 17th editor in chief of JAMA and the JAMA Network. In conversation with Nobel laureate Harold Varmus, MD, Bibbins-Domingo discusses her research background, approaches to leadership in health care, and the critical role that journals play in communication about public health and science.
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Carpal tunnel syndrome and trigger finger are common hand conditions in primary care practice that are associated with pain and disability. In this JAMA podcast, JAMA Deputy Editor Mary M. McDermott, MD, and Kelly Currie, MD, assistant professor in the Washington University Division of Plastic & Reconstructive Surgery in St Louis, Missouri, discuss the diagnosis and treatment of these conditions and other hand problems that are commonly encountered in primary care.
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JAMA Associate Editor Ethan Basch, MD, and Melanie Calvert, PhD, from the University of Birmingham, UK, discuss barriers to and strategies for including rigorous patient-reported outcomes in clinical trials, and reflect on Dr Calvert’s recent JAMA paper on related ethical implications.
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Ethical Considerations for the Inclusion of Patient-Reported Outcomes in Clinical Research
JAMA Associate Editor Linda Brubaker, MD, MS, from University of California San Diego, discusses the implications of self-monitoring of blood pressure in higher-risk pregnancies with Richard J. McManus, MBBS, PhD, from University of Oxford, UK, and Lucy C. Chappell, MB BChir, PhD, from King's College London.
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Lumbar spinal stenosis is a common cause of low back pain and disability in older people. Both nonoperative and operative therapies can improve symptoms from spinal stenosis. In this podcast, Jeffrey Katz, MD, MSc, from Harvard Medical School joins JAMA Deputy Editor Mary M. McDermott, MD, to discuss current evidence regarding diagnosis and optimal treatment of lumbar spinal stenosis, including when to consider invasive therapies for patients with symptoms of lumbar spinal stenosis.
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After certain adverse pregnancy outcomes, an individual’s risk for cardiovascular and other diseases increases. JAMA Associate Editor Linda Brubaker, MD, discusses these complications as indicators of future health problems, who is at risk, and what can be done to improve health for at-risk individuals and populations with Lynn M. Yee, MD, MPH, and JAMA Senior Editor Philip Greenland, MD, from Northwestern University, and Eliza C. Miller, MD, MS, from Columbia University.
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Pulmonary arterial hypertension is a rare condition that requires a thorough workup to evaluate for potential causes and right heart catheterization for definitive diagnosis and decision-making about treatment options. JAMA Associate Editor Kristin Walter, MD, MS, discusses the recent JAMA review article titled “Pulmonary Arterial Hypertension Classification, Diagnosis, and Treatment” with one of the authors, Nicole Ruopp, MD, assistant professor of medicine at Tufts Medical Center and Tufts University School of Medicine.
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Epilepsy affects approximately 65 million people worldwide and is associated with increased rates of bodily injuries and mortality when not optimally treated. The primary goal of epilepsy treatment is to eliminate seizures while minimizing adverse effects of antiseizure drugs. JAMA Senior Editor Christopher Muth, MD, and Professor of Clinical Neurology at the University of Miami Miller School of Medicine Andres Kanner, MD, discuss establishing a diagnosis of epilepsy and the use of antiseizure medications for adult patients with epilepsy.
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More than 200 000 individuals in the US develop acute cholecystitis annually. The majority of these cases are caused by gallstones blocking the cystic duct. However, about 5% to 10% of people with acute cholecystitis have acalculous cholecystitis. JAMA Associate Editor Kristin Walter, MD, MS, discusses the recent JAMA article “Acute Cholecystitis: A Review” with one of the authors, JAMA Associate Editor Anthony Charles, MD, MPH, who is Chief of the Division of Trauma, Critical Care and Acute Care Surgery, Director of the ECMO program, and Director of Global Surgery at University of North Carolina in Chapel Hill.
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Treatment strategies for acute ischemic stroke are continuing to evolve. JAMA Associate Editor and vascular neurologist Jeffrey Saver, MD, from the University of California Los Angeles, and JAMA Senior Editor Christopher Muth, MD, discuss 2 articles recently published in JAMA about alteplase in the treatment of acute ischemic stroke and provide a broader overview of the recent advances and future directions for the use of thrombolytics and endovascular thrombectomy for acute ischemic stroke.Treatment strategies for acute ischemic stroke are continuing to evolve. JAMA Associate Editor and vascular neurologist Jeffrey Saver, MD, from the University of California Los Angeles, and JAMA Senior Editor Christopher Muth, MD, discuss 2 articles recently published in JAMA about alteplase in the treatment of acute ischemic stroke, and provide a broader overview of the recent advances and future directions for the use of thrombolytics and endovascular thrombectomy for acute ischemic stroke.
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Pregnant and recently pregnant individuals who become infected with the COVID-19 virus are at high risk of requiring extra medical care. JAMA Associate Editor Linda Brubaker, MD, MS, from University of California San Diego discusses the rapidly evolving data around COVID-19 and vaccine effectiveness and safety as it relates to pregnancy, breastfeeding, and fertility with 3 experts in the field: Laura E. Riley, MD, from Weill Cornell Medicine, Christina Chambers, PhD, MPH, from University of California San Diego School of Medicine-Pediatrics, and Denise Jamieson, MD, MPH, from Emory University.
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Conflict of Interest Disclosures:
Dr Chambers reported receiving research funding from Pfizer-BioNTech to study the safety of its COVID-19 vaccine in pregnancy.
Dr Jamieson reported no disclosures.
Dr Riley reported receiving compensation from UpToDate for work on several infections disease cards, receiving royalties from Turner Publishing, and serving on an advisory board for Maven. Dr Riley also reported serving on a CDC Advisory Committee on Immunization Practices workgroup on COVID-19 vaccines and vaccine safety and workgroups for the American College of Obstetricians and Gynecologists and Society for Maternal-Fetal Medicine of COVID-19 vaccination, without compensation.
Acute coronary syndromes are characterized by a sudden reduction in blood supply to the heart, and the syndromes include ST-segment elevation myocardial infarction (or STEMI), non-ST-segment elevation myocardial infarction (or NSTEMI), and unstable angina. Each year, an estimated more than 7 million people in the world are diagnosed with acute coronary syndromes, including more than 1 million people hospitalized in the US. In this podcast with Deepak L. Bhatt, MD, MPH, of Brigham and Women’s Hospital Heart and Vascular Institute, we bring our listeners up-to-date on these common and potentially serious conditions.
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Tobacco smoking is responsible for more deaths in the US each year than any other preventable cause of mortality. Approximately 14% of US adults smoke cigarettes, of whom an estimated 70% want to quit smoking. JAMA Associate Editor Kristin Walter, MD, MS, discusses the recent JAMA article titled “Treatment of Smoking Cessation—A Review” with one of the authors, Nancy Rigotti, MD, who is director of the Tobacco Research and Treatment Center at Massachusetts General Hospital and is a professor at Harvard Medical School.
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Multiple myeloma is a hematologic malignancy characterized by abnormal plasma cells in the bone marrow, with potential uncontrolled growth causing destructive bone lesions, kidney injury, anemia, and hypercalcemia. Edward Libby, MD, of the University of Washington, joins JAMA Associate Editor Ethan Basch, MD, of the University of North Carolina, for a discussion of the diagnosis, complications, and management of myeloma, as well as the related conditions of monoclonal gammopathy of undetermined significance (MGUS) and smoldering myeloma.
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Approximately 1 in 5 adults in the US had a sexually transmitted infection in 2018. Khalil Ghanem, MD, PhD, of Johns Hopkins University joins JAMA Deputy Editor Mary McDermott, MD, to discuss the newest recommendations regarding the diagnosis and treatment of sexually transmitted infections, including gonorrhea, chlamydia, syphilis, Mycoplasma genitalium, and trichomoniasis.
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Pulmonary nodules are commonly found on lung imaging studies. Evaluation and management depends on the size and other characteristics of pulmonary nodules and patient risk factors for malignancy. JAMA Associate Editor Kristin Walter, MD, MS, discusses the recent JAMA article “Evaluating the Patient With a Pulmonary Nodule: A Review” with one of the authors, Peter Mazzone, MD, MPH, a pulmonologist and director of the Lung Cancer Program for the Respiratory Institute at the Cleveland Clinic.
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The last few years have seen a tremendous increase in the conduct of platform clinical trials, a type of randomized clinical trial that can simultaneously evaluate the effects of multiple interventions, often in combination, with the available treatments changing over time as more is learned about their effectiveness. Jay J.H. Park, PhD, and Edward J. Mills, PhD, from the University of British Columbia and McMaster University, respectively, join JAMA Statistical Editor Roger J. Lewis, MD, PhD, to discuss how clinicians should evaluate the results of platform clinical trials when considering incorporating the results into their clinical practice.
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Approximately 87% of US women will use contraception during their lifetime. Stephanie Teal, MD, MPH, from University Hospitals Cleveland Medical Center, and JAMA Associate Editor Linda Brubaker, MD, MS, from University of California San Diego, discuss factors to consider during contraception selection, balancing highest effectiveness and lowest risks.
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Nearly all pregnant individuals use at least 1 medication, either prescribed or over-the-counter, during their pregnancy. Denise Jamieson, MD, MPH, professor and chair of Gynecology and Obstetrics at Emory University in Atlanta, Georgia, joins JAMA Associate Editor Linda Brubaker, MD, MS, to discuss the current FDA system and other resources for communicating medication safety data to clinicians.
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Assessment of the Safety of Common Medications Used During Pregnancy
Appendectomy remains the first-line therapy for acute appendicitis, but treatment with antibiotics rather than surgery is appropriate in selected patients with uncomplicated appendicitis. JAMA Associate Editor Anthony Charles, MD, MPH, from UNC School of Medicine summarizes this and other aspects of acute appendicitis in adults along with author Theodore N. Pappas, MD, from Duke University Medical Center.
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