Chronic lymphocytic leukemia (CLL) affects more than 200 000 people and is associated with >4000 deaths in the US annually. Many people have asymptomatic disease and can be monitored without treatment for long periods. In this podcast, author Mazyar Shadman, MD, MPH, from the University of Washington, Seattle, joins JAMA Deputy Editor Mary M. McDermott, MD, in a discussion about diagnosis and management of CLL.

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• Diagnosis and Treatment of Chronic Lymphocytic Leukemia

Approximately 3 million people in the US have heart failure with preserved ejection fraction (HFpEF). JAMA Executive Editor Gregory Curfman, MD, discusses diagnosis and treatment of HFpEF with authors Margaret Redfield, MD, and Barry Borlaug, MD, both from Mayo Foundation for Medical Education and Research Division of Cardiovascular Diseases.

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• Heart Failure With Preserved Ejection Fraction

More than 2 million individuals in the US are chronically infected with hepatitis C, and nearly 15 000 die every year. Antivirals are available but are not reaching the majority of infected individuals. In this Q&A, JAMA Editor in Chief Kirsten Bibbins-Domingo, PhD, MD, MAS, and Francis S. Collins, MD, PhD, discuss a plan to eliminate hepatitis C included in the Biden-Harris 2024 budget proposal.

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• A National Hepatitis C Elimination Program in the United States
• Eliminating Hepatitis C in the United States
• Former NIH Director Francis S. Collins on the New White House Plan to Eliminate Hepatitis C
• Association of Direct-Acting Antiviral Therapy With Liver and Nonliver Complications and Long-term Mortality in Patients With Chronic Hepatitis C
• After 12 Years, NIH Director Francis S. Collins, MD, PhD, Seeks His Next Chapter
• After 12 Years, NIH Director Francis S. Collins Seeks His Next Chapter